Spindle Cell Oncocytomas of the Pituitary Gland McAfee, and Richard Prayson, MD, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, US)Ĭhapter 2. Pituicytoma: A Clinicopathologic Review of a Rare Glial Neoplasm of the Pituitary (Imprint: Nova Medicine and Health) BindingĬhapter 1. The hypothalamic-pituitary-adrenal axis is activated during stress, which leads to the secretion of cortisol and aldosterone from the adrenal gland. The closing study explores hypothalamic-pituitary-adrenal axis activation, a potent and complex response to heat stress in domestic livestock. Glucocorticoids are widely used for the treatment of various inflammatory conditions and malignancies, as well as after organ transplantation. The risk of developing adrenal insufficiency among glucocorticoid users is assessed, and risk factors are identified. Mineralocorticoids, glucocorticoids and adrenal androgens are synthesized respectively in the zona glomerulosa, zona fasciculatis and zona reticularis that make up the cortex, while the inner adrenal medulla produces the catecholamines and peptides. This compilation goes on to examine the adrenal glands, paired structures located superior to the kidneys in the retroperitoneal space. The clinicopathologic features of granular tumors, rare neoplasms that most commonly arise in the neurohypophysis or posterior portion of the pituitary gland, are also discussed. They are most commonly seen in children and young adults, and most often arise in the cerebellum as part of Cowden’s disease, or in the sellar region. Tumors typically present in adults and most commonly manifest with visual disturbances and pituitary hypofunction.Īdditionally, the authors review the clinical and pathological features of gangliocytomas, rare benign tumors of the neuroaxis. Spindle cell oncocytomas are rare tumors, accounting for less than 0.5% of sellar masses. They typically present with signs and symptoms of a slow growing, non-hormonally active mass of the sellar and suprasellar region, compressing adjacent structures.įollowing this, the clinical and pathologic features of spindle cell oncocytomas are discussed. In The Pituitary Gland and Adrenal Glands: New Research, the authors first discuss pituicytomas, rare primary glial neoplasms that arise in the neurohypophysis (or posterior portion) of the pituitary gland. Series: Endocrinology Research and Clinical Developments

Pituitary adrenal glands